Chemical Physics Seminar: Xenon Hosts for CEST-Enhanced NMR with Hyperpolarized Nuclei

Abstract:

​Nuclear Magnetic Resonance suffers from low sensitivity for spectroscopy and imaging applications. For certain applications, this sensitivity issue can be solved by means of hyperpolarized xenon that is reversibly bound to host structures. Application of saturation transfer pulses allows for further sensitivity enhancement (Hyper-CEST technique). Thus, the host structure has a direct impact on exchange kinetics and the amount of participating xenon. It becomes an important feature to tune the achievable CEST effect for improved sensitivity and different ranges of selectivity in systems with binding of competitive guests. This talk will give an overview of the performance of different hosts with applications in xenon biosensor MRI and NMR analysis of different host-guest systems.